Research & Publications

August 17, 2016


Current research projects


Dr Sam Mehr is currently involved in the following research projects

  1. PEPITES trial (to determine whether the application of a peanut patch on the skin of children with peanut allergy will assist in desentisiation/tolerance)
  2. BOPIA trial (to determine whether peanut ingestion + a fibre supplement in children with a peanut allergy will assist in desensitisatio/tolerance; NHMRC funded study. Study due to launch in 2017)
  3. Molecular characterisation of food allergens causing IgE mediated reactions in those with fish, shellfish and nut allergies
  4. FPIES trials
    a. Determine the pathophysiology of children with FPIES (funded by AIFA; see http://www.allergyimmunology.org.au/projects/understanding-fpies; study underway)
    b. Determine various epidemiological aspects of FPIES reactions across Australia (submitted to JACI; awaiting outcome)
    c. Determine whether there are simple markers to help distinguish FPIES from other common pediatric conditions such as sepsis and gastroenteritis (study still underway)

Publications


2017

Immunodeficiency in CHARGE syndrome.
Mehr S, Hsu P, Campbell D.
Am J Med Genet C Semin Med Genet. 2017 Nov 21. doi: 10.1002/ajmg.c.31594. [Epub ahead of print] Review.

 

Accidental self-injection with adrenaline auto-injectors occurs frequently but is under-reported.
Latt MD, George S, Ngo P, Brown JA, Mehr S.
J Paediatr Child Health. 2017 Jul;53(7):724-725. doi: 10.1111/jpc.13553. No abstract available.

 

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency.
Munoz MA, Jurczyluk J, Mehr S, Chai RC, Arts RJW, Sheu A, McMahon C, Center JR, Singh-Grewal D, Chaitow J, Campbell DE, Quinn JMW, Alexandrov K, Tnimov Z, Tangye SG, Simon A, Phan TG, Rogers MJ.
J Allergy Clin Immunol. 2017 Sep;140(3):873-875.e6. doi: 10.1016/j.jaci.2017.02.033. Epub 2017 May 10.

 

Food protein-induced enterocolitis syndrome in Australia: A population-based study, 2012-2014.
Mehr S, Frith K, Barnes EH, Campbell DE; FPIES Study Group.
J Allergy Clin Immunol. 2017 Nov;140(5):1323-1330. doi: 10.1016/j.jaci.2017.03.027. Epub 2017 Apr 18.

 

Resolution of acute food protein-induced enterocolitis syndrome in children.
Lee E, Campbell DE, Barnes EH, Mehr SS.
J Allergy Clin Immunol Pract. 2017 Mar – Apr;5(2):486-488.e1. doi: 10.1016/j.jaip.2016.09.032. Epub 2016 Nov 9.

 


2016

Tan JW, Valerio C, Barnes EH, Turner PJ, Van Asperen PA, Kakakios AM, Campbell DE; BEAT Study Group (Mehr S).  A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergyJ Allergy Clin Immunol. 2016 Oct 11. pii: S0091-6749(16)31118-6. doi: 10.1016/j.jaci.2016.08.035. [Epub ahead of print]


Mehr S, Allen R, Boros C, Adib N, Kakakios A, Turner PJ, Rogers M, Zurynski Y, Singh-Grewal D. Cryopyrin-associated periodic syndrome in Australian children and adults: Epidemiological, clinical and treatment characteristicsJ Pediatr Child Health. 2016. Sep;52(9):889-95. doi: 10.1111/jpc.13270.


Miceli Sopo S, Bersani G, Monaco S, Cerchiara G, Lee E, Campbell D, Mehr SOndansetron in acute food protein-induced enterocolitis syndrome, a retrospective case-control studyAllergy. 2016 Aug 22. doi: 10.1111/all.13033. [Epub ahead of print]


Jurczyluk J, Munoz MA, Skinner OP, Chai RC, Ali N, Palendira U, Quinn JM, Preston A, Tangye SG, Brown AJ, Argent E, Ziegler JB, Mehr S, Rogers MJ. Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPasesImmunol Cell Biol. 2016 Jul 5. doi: 10.1038/icb.2016.58. [Epub ahead of print] PubMed PMID: 27377765.


Wong MT, van Ravenswaaij-Arts CM, Munns CF, Hsu P, Mehr S, Bocca G. Central Adrenal Insufficiency Is Not a Common Feature in CHARGE Syndrome: A Cross-Sectional Study in 2 Cohorts. J Pediatr. 2016 Jun 16. pii: S0022-3476(16)30339-0. doi: 10.1016/j.jpeds.2016.05.065. [Epub ahead of print] PubMed PMID: 27321065.


Pandit C, Hsu P, van Asperen P, Mehr S. Respiratory manifestations and management in children with Common Variable Immunodeficiency. Paediatr Respir Rev. 2016 Jun;19:56-61. doi: 10.1016/j.prrv.2015.12.003. Epub 2016 Jan 5. Review. PubMed PMID: 26831679.


Hsu P, Ma A, Barnes EH, Wilson M, Hoefsloot LH, Rinne T, Munns C, Williams G, Wong M, Mehr S. The Immune Phenotype of Patients with CHARGE Syndrome. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):96-103.e2. doi: 10.1016/j.jaip.2015.09.004. Epub 2015 Nov 7. PubMed PMID: 26563674.


Turner PJ, Allen KJ, Mehr S, Campbell DE. Knowledge, practice, and views on precautionary allergen labeling for the management of patients with IgE-mediated food allergy–a survey of Australasian and UK health care professionals. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):165-7.e14. doi: 10.1016/j.jaip.2015.09.003. Epub 2015 Oct 21. PubMed PMID: 26489715.


2015

Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. Review. PubMed PMID: 25956013.


Lee E, Mehr S, Turner PJ, Joshi P, Campbell DE. Adherence to extensively heated egg and cow’s milk after successful oral food challenge. J Allergy Clin Immunol Pract. 2015 Jan-Feb;3(1):125-7.e4. doi: 10.1016/j.jaip.2014.08.013. Epub 2014 Oct 29. PubMed PMID: 25577635.


Campbell DE, Mehr S. Fifty years of allergy: 1965-2015. J Paediatr Child Health. 2015 Jan;51(1):91-3. doi: 10.1111/jpc.12806. PubMed PMID: 25586850.


2014

 

Mehr S, Turner PJ, Joshi P, Wong M, Campbell DE. Safety and clinical predictors of reacting to extensively heated cow’s milk challenge in cow’s milk-allergic children. Ann Allergy Asthma Immunol. 2014 Oct;113(4):425-9. doi: 10.1016/j.anai.2014.06.023. Epub 2014 Jul 22. PubMed PMID: 25065571.


Turner PJ, Mehr S, Sayers R, Wong M, Shamji MH, Campbell DE, Mills EN. Loss of allergenic proteins during boiling explains tolerance to boiled peanut in peanut allergy. J Allergy Clin Immunol. 2014 Sep;134(3):751-3. doi: 10.1016/j.jaci.2014.06.016. Epub 2014 Jul 25. PubMed PMID: 25065723.


Hsu P, Ma A, Wilson M, Williams G, Curotta J, Munns CF, Mehr S. CHARGE syndrome: a review. J Paediatr Child Health. 2014 Jul;50(7):504-11. doi: 10.1111/jpc.12497. Epub 2014 Feb 19. Review. PubMed PMID: 24548020.


Mehr S, Frith K, Campbell DE. Epidemiology of food protein-induced enterocolitis syndrome. Curr Opin Allergy Clin Immunol. 2014 Jun;14(3):208-16. doi: 10.1097/ACI.0000000000000056. Review. PubMed PMID: 24686277; PubMed Central PMCID: PMC4011623.


2013

 

Tan JW, Campbell DE, Turner PJ, Kakakios A, Wong M, Mehr S, Joshi P. Baked egg food challenges – clinical utility of skin test to baked egg and ovomucoid in children with egg allergy. Clin Exp Allergy. 2013 Oct;43(10):1189-95. doi: 10.1111/cea.12153. PubMed PMID: 24074337.


Turner PJ, Mehr S, Joshi P, Tan J, Wong M, Kakakios A, Campbell DE. Safety of food challenges to extensively heated egg in egg-allergic children: a prospective cohort study. Pediatr Allergy Immunol. 2013 Aug;24(5):450-5. doi: 10.1111/pai.12093. Epub 2013 Jun 16. PubMed PMID: 23773122.


Gray PE, Mehr S, Katelaris CH, Wainstein BK, Star A, Campbell D, Joshi P, Wong M, Frankum B, Keat K, Dunne G, Dennison B, Kakakios A, Ziegler JB. Salicylate elimination diets in children: is food restriction supported by the evidence? Med J Aust. 2013 Jun 17;198(11):600-2. PubMed PMID: 23919705.


Hsu P, Mehr S. Egg: a frequent trigger of food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2013 Jan;131(1):241-2. doi: 10.1016/j.jaci.2012.08.045. Epub 2012 Oct 12. PubMed PMID: 23069493.


2012

Mehr S, Wood N. Streptococcus pneumoniae–a review of carriage, infection, serotype replacement and vaccination. Paediatr Respir Rev. 2012 Dec;13(4):258-64. doi: 10.1016/j.prrv.2011.12.001. Epub 2012 Jan 18. Review. PubMed PMID: 23069126.


Mehr S. The immunological investigation of a child with chronic wet cough. Paediatr Respir Rev. 2012 Sep;13(3):144-9. doi: 10.1016/j.prrv.2012.02.001. Epub 2012 Mar 2. Review. PubMed PMID: 22726869.


Tan J, Mehr S. Anaphylaxis to an ondansetron wafer. J Paediatr Child Health. 2012 Jun;48(6):543-4. doi: 10.1111/j.1440-1754.2011.02124.x. Epub 2011 Jun 17. PubMed PMID: 21679335.


Tan J, Campbell D, Mehr S. Food protein-induced enterocolitis syndrome in an exclusively breast-fed infant-an uncommon entity. J Allergy Clin Immunol. 2012 Mar;129(3):873, author reply 873-4. doi: 10.1016/j.jaci.2011.12.1000. Epub 2012 Jan 31. PubMed PMID: 22296754.


Mehr S, Brown S. A case of ant anaphylaxis. J Paediatr Child Health. 2012 Mar;48(3):E101-4. doi: 10.1111/j.1440-1754.2010.01877.x. Epub 2010 Oct 6. PubMed PMID: 22417473.

 

2011 and earlier

 

Turner PJ, Kemp AS, Rogers M, Mehr S. Refractory symptoms successfully treated with leukotriene inhibition in a child with systemic mastocytosis. Pediatr Dermatol. 2012 Mar-Apr;29(2):222-3. doi: 10.1111/j.1525-1470.2011.01576.x. Epub 2011 Nov 2. PubMed PMID: 22044360.


Mehr S, Kakakios A, Shaw P, Webster R, Kemp A. Beware the lymphopenia: a case of severe combined immunodeficiency. J Paediatr Child Health. 2011 Aug;47(8):565-7. doi: 10.1111/j.1440-1754.2010.01870.x. Epub 2010 Oct 6. PubMed PMID: 21843190.


Murphy A, Campbell DE, Baines D, Mehr S. Allergic reactions to propofol in egg-allergic children. Anesth Analg. 2011 Jul;113(1):140-4. doi: 10.1213/ANE.0b013e31821b450f. Epub 2011 Apr 5. PubMed PMID: 21467558.


Turner PJ, Mehr S, Kemp AS. Detection of pulmonary complications in common variable immunodeficiency. Pediatr Allergy Immunol. 2011 Jun;22(4):449-50; author reply 451-2. doi: 10.1111/j.1399-3038.2010.01118.x. PubMed PMID: 21535182.


Mehr S. A pigmented rash. J Paediatr Child Health. 2011 Mar;47(3):149, 157. doi: 10.1111/j.1440-1754.2011.02062_1.x. PubMed PMID: 21401776.


Mehr S, Jones KJ, Singh-Grewal D, Aksentijevich I, Kakakios A. Chronic urticaria of neonatal onset: a potential sign of autoinflammation. J Paediatr Child Health. 2010 Oct;46(10):608-10. doi: 10.1111/j.1440-1754.2009.01688.x. PubMed PMID: 20163528.


Mehr SS, Kemp AS. Prolonged varicella viraemia and streptococcal toxic shock syndrome following varicella vaccination of a health care worker. Med J Aust. 2009 Oct 5;191(7):413-4. PubMed PMID: 19807643.


Mehr S, Liew WK, Tey D, Tang ML. Clinical predictors for biphasic reactions in children presenting with anaphylaxis. Clin Exp Allergy. 2009 Sep;39(9):1390-6. doi: 10.1111/j.1365-2222.2009.03276.x. Epub 2009 May 26. PubMed PMID: 19486033.


Mehr S, Rego S, Kakakios A, Kilham H, Kemp A. Treatment of a case of pediatric hypereosinophilic syndrome with anti-interleukin-5. J Pediatr. 2009 Aug;155(2):289-91. doi: 10.1016/j.jpeds.2009.01.058. PubMed PMID: 19619754.


Mehr SS, Kakakios AM, Kemp AS. Rice: a common and severe cause of food protein-induced enterocolitis syndrome. Arch Dis Child. 2009 Mar;94(3):220-3. doi: 10.1136/adc.2008.145144. Epub 2008 Oct 28. PubMed PMID: 18957470.


Mehr S, Kakakios A, Frith K, Kemp AS. Food protein-induced enterocolitis syndrome: 16-year experience. Pediatrics. 2009 Mar;123(3):e459-64. doi: 10.1542/peds.2008-2029. Epub 2009 Feb 2. PubMed PMID: 19188266.


Mehr S, Wong M. The impact of the measurement of uncertainty. Intern Med J. 2009 Jan;39(1):70. doi: 10.1111/j.1445-5994.2008.01819.x. PubMed PMID: 19290990.


Fehon R, Mehr S, La Hei E, Isaacs D, Wong M. Two-year-old boy with cervical and liver abscesses. J Paediatr Child Health. 2008 Nov;44(11):670-2. doi: 10.1111/j.1440-1754.2008.01398.x. PubMed PMID: 19012643.


Mehr SS, Kemp AS. Feeding choice for children with immediate allergic reactions to cows milk protein. Med J Aust. 2008 Aug 4;189(3):178-9. PubMed PMID: 18673111.


de Silva IL, Mehr SS, Tey D, Tang ML. Paediatric anaphylaxis: a 5 year retrospective review. Allergy. 2008 Aug;63(8):1071-6. doi: 10.1111/j.1398-9995.2008.01719.x. PubMed PMID: 18691309.


Mehr S, Robinson M, Tang M. Doctor–how do I use my EpiPen? Pediatr Allergy Immunol. 2007 Aug;18(5):448-52. PubMed PMID: 17617813.


Boyle RJ, Russo VC, Andaloro E, Mehr SM, Tang ML. Anaphylaxis to kangaroo meat: identification of a new marsupial allergen. Allergy. 2007 Feb;62(2):209-11. PubMed PMID: 17298433.


Mehr SS, Sadowsky JL, Doyle LW, Carr J. Sepsis in neonatal intensive care in the late 1990s. J Paediatr Child Health. 2002 Jun;38(3):246-51. PubMed PMID:12047691.


Mehr SS, Doyle LW, Rice GE, Vervaart P, Henschke P. Interleukin-6 and interleukin-8 in newborn bacterial infection. Am J Perinatol. 2001 Sep;18(6):313-24. PubMed PMID: 11607849.


Mehr S, Doyle LW. Cytokines as markers of bacterial sepsis in newborn infants: a review. Pediatr Infect Dis J. 2000 Sep;19(9):879-87. Review. PubMed PMID: 11001114.


Davies MW, Mehr S, Garland ST, Morley CJ. Bacterial colonization of toys in neonatal intensive care cots. Pediatrics. 2000 Aug;106(2):E18. PubMed PMID:10920174.


Davies MW, Mehr S, Morley CJ. The effect of draw-up volume on the accuracy of electrolyte measurements from neonatal arterial lines. J Paediatr Child Health. 2000 Apr;36(2):122-4. PubMed PMID: 10760008.


Mehr SS, Davies MW. Clotting profiles and coagulation factors. Arch Dis Child Fetal Neonatal Ed. 1999 Jul;81(1):F77. PubMed PMID: 10744433; PubMed Central PMCID: PMC1720971.


Mehr S, Doyle L. Interleukin-6 concentrations in neonatal sepsis. Lancet. 1999 May 22;353(9166):1798-9. PubMed PMID: 10348018.