FPIES is associated with activation of the innate immune system

Our findings on the mechanism underpinning acute FPIES reactions was published today in the Journal of Allergy and Clinical Immunology (https://www.jacionline.org/article/S0091-6749(19)30605-0/abstract).

We found  in children having an acute FPIES reaction, there was activation of the innate immune system (this is the part of the immune system normally provides us with rapid defense against pathogens; but in this case, is causing a rapid reaction against a food protein). This is one piece in the puzzle of trying to understand the pathways activated in FPIES, and may allow us to find blood markers to assist with diagnosis of FPIES or enable us to determine if a child has outgrown the condition without a formal food challenge. I would like to thank the Allergy and Immunology Foundation of Australasia (AIFA) that provided all the necessary funding for this study.